The effects of aqueous extract of ocimum gratissimum on the cerebellum of male wistar rats challenged by lead acetate

•Chronic lead acetate toxicity was induced in male rats by oral administration.•Effect of Ocimum gratissimum on the cerebellum.•Oral administration led to oxidative stress cerebellum.•Ocimum extract attenuated and enhanced antioxidant enzymes.•Ocimum ameliorated acetate-induced cerebellum. ObjectivesLead (LA) is a known toxicant, its exposure environment has been increase recent times, leading tissue damage. Based this background, we investigated role antioxidative properties (OG), potent medicinal plant, ameliorating protecting brain from cerebellar damage via assessment parameters histology.MethodsThirty-five adult Wistar weighing 145–200g divided into five groups were used for experimental study. Groups 1, 2, 3 served as positive negative controls administered sterile water, 252.98 mg/kg body weight aqueous leaves OG 120 LA 21 days. Furthermore, following LA, 4 5 treated with 125 250 OG. orally 42 Oxidative parameters, well histoarchitectural investigations treatment, analysed.ResultsResults showed normal histoarchitecture cerebellum control group 2 animals (OG only). In that received only, observed severe stages neurodegenerative features Purkinje, granular cell molecular layers Cerebellum. Also, results co-administered revealed regenerative tendencies an neuronal density Nevertheless, recorded content malondialdehyde decreased status (catalase (CAT), glutathione (GSH), sodium dismutase (SOD)) administration. heightened MDA activity depletion status.ConclusionOverall, these findings suggest improved neurotoxicity degeneration exposed modulating Lead histology. Thirty-five analysed. Results status. Overall,